In-line liquid concentration measurements for pharmaceutical drug manufacturing and biotechnology processes Increase yield, produce on-spec products always and lower production costs Vaisala K-PATENTS? refractometers provide continuous and accurate, reliable, repeatable and reproducible measurements for applications aligned with Process Analytical Technology (PAT) manufacturing methods. ??? ?Process data for every batch or lot via the Ethernet. ??? ?Aids in compliance with cGMP (Current Good Manufacturing Practice)? ??? ?Sanitary 3-A and EHEDG certified. ??? ?Audit trail and access controls for 21 CFR Part 11 compliance.? ??? ?Traceable calibration and verification.? ??? ?IQ/OQ documentation for validation.? Applications in pharmaceuticals manufacturing Active Pharmaceutical Ingredients (API) production and pharmaceuticals processing?at all scales in small molecules medicines manufacturing, and throughout the manufacturing line from reaction monitoring to downstream processes such as crystallization and filter cake washing. Download our application notes for more information.? Production of Active Pharmaceutical Ingredients (API) Real-time concentration measurements during reaction, crystallization, separation and purification, filter cake washing, solvent swap and solvent exchange?for the development and production of APIs. Solvent swap or solvent exchange Monitor your solvent swap operation during API production by measuring the concentrations of the original and swap solvents.? Pharmaceutical crystallization Determine exact seeding point and yield only high-quality crystals during API production.? Filter cake washing Acquire deep process understanding by measurement data, develop unique washing profiles and find the most suitable washing solvent for increased yield and maximum wash result.? Aspirin crystallization Measure liquid phase in aspirin (acetylsalicylic acid) crystallization and control your crystallization process. ? Pharmaceutical extraction: herbal-based medicine Always achieve your target extract concentration during solid-liquid extraction (leaching).? Applications in biotechnology processes Timely measurements for the development and monitoring of biopharmaceuticals processing such as fermentation, cell culture, protein buffer solutions and concentration. Download our application notes for more information.? Pharmaceutical fermentation Measurement solutions for standardizing and automating processes. From fermentation profile design to scale-up and for determining the endpoint of fermentation instantly and reliably with no deviations on full-scale production. Vaccines production Collect only the virus fraction with correct density for best yield in purification operations/downstream processes.? Protein concentration and filtration Control retentate concentration for good permeability even with the smallest of particles.? Penicillin production Measure concentration of raw penicillin, monitor fermentation process and maintain optimal conditions with high yield during production.? L-Lysine evaporation process Control your evaporation process with an industrial process refractometer.? Medical applications Wound dressing, medical implants manufacturing and medical protective wear.? Download our application notes for more information.? Alginate wound dressings and fabrics Monitor alginate dope solution and coagulation bath concentrations in wet-spinning for operations for best fiber quality.? Medical implants and device surface treatments Monitor and control acid (for example nitric acid HNO3) during medical parts passivation to meet product specifications. Dipping baths in rubber and medical gloves manufacturing Ensure protective clothing's critical final?quality and durability?by measuring Total Dissolved Solids (TDS) in liquid latex, nitrile, vinyl or synthetic polyisoprene dipping baths.? Related products Vaisala K?PATENTS? Pharma Refractometer PR-43-PC for in-line liquid concentration measurements in pharmaceutical drug manufacturing and biochemicals processes Vaisala K?PATENTS? Sanitary Compact Refractometer PR-23-AC for Brix and concentration measurement Blogs, webinars and success stories Read our latest blogs and listen to the webinar on pharmaceutical drug manufacturing.? Q&A from our webinar: Fast and efficient viral vaccines purification by sucrose density gradient Liquid Measurements Industrial Measurements Life Science Read more The six most important things to consider when selecting an in-line liquid measurement device for pharmaceutical drug manufacturing Liquid Measurements Industrial Measurements Life Science Read more Vaisala contributes to health and well-being, helping develop medicines such as a vaccine for COVID-19 Liquid Measurements Sustainability Life Science Read more Pagination Next page ?? Fast and efficient viral vaccines purification by sucrose density gradient In this 30-minute webinar (+ 15 minutes for Q&A), Vaisala's Liquid Measurements pharmaceutical experts will explain the benefits of the refractive index technology and how it helps downstream processes during purification of viral vaccines manufacturing. Watch the webinar Refractive index in development and production of Active Pharmaceutical Ingredients (APIs) Learn from real customer cases how in-line process refractometers can be used as a PAT tool for? standardizing and scaling-up APIs production.? Watch the webinar Humidity and Temperature Probe HMP1 for wall mounting Vaisala HUMICAP? Humidity and Temperature Probe HMP1 is designed for measuring ambient measurement in indoor?spaces. HMP1 can... Read more Can't find your application? Only some examples of our refractometer applications are listed here. There are still hundreds more! Our application experts will help you. Tell us a bit more by filling the form or contact us. Contact Form
In-line liquid concentration measurements for pharmaceutical drug manufacturing and biotechnology processes Increase yield, produce on-spec products always and lower production costs
Applications in pharmaceuticals manufacturing Active Pharmaceutical Ingredients (API) production and pharmaceuticals processing?at all scales in small molecules medicines manufacturing, and throughout the manufacturing line from reaction monitoring to downstream processes such as crystallization and filter cake washing. Download our application notes for more information.? Production of Active Pharmaceutical Ingredients (API) Real-time concentration measurements during reaction, crystallization, separation and purification, filter cake washing, solvent swap and solvent exchange?for the development and production of APIs. Solvent swap or solvent exchange Monitor your solvent swap operation during API production by measuring the concentrations of the original and swap solvents.? Pharmaceutical crystallization Determine exact seeding point and yield only high-quality crystals during API production.? Filter cake washing Acquire deep process understanding by measurement data, develop unique washing profiles and find the most suitable washing solvent for increased yield and maximum wash result.? Aspirin crystallization Measure liquid phase in aspirin (acetylsalicylic acid) crystallization and control your crystallization process. ? Pharmaceutical extraction: herbal-based medicine Always achieve your target extract concentration during solid-liquid extraction (leaching).?
Production of Active Pharmaceutical Ingredients (API) Real-time concentration measurements during reaction, crystallization, separation and purification, filter cake washing, solvent swap and solvent exchange?for the development and production of APIs.
Solvent swap or solvent exchange Monitor your solvent swap operation during API production by measuring the concentrations of the original and swap solvents.?
Pharmaceutical crystallization Determine exact seeding point and yield only high-quality crystals during API production.?
Filter cake washing Acquire deep process understanding by measurement data, develop unique washing profiles and find the most suitable washing solvent for increased yield and maximum wash result.?
Aspirin crystallization Measure liquid phase in aspirin (acetylsalicylic acid) crystallization and control your crystallization process. ?
Pharmaceutical extraction: herbal-based medicine Always achieve your target extract concentration during solid-liquid extraction (leaching).?
Applications in biotechnology processes Timely measurements for the development and monitoring of biopharmaceuticals processing such as fermentation, cell culture, protein buffer solutions and concentration. Download our application notes for more information.? Pharmaceutical fermentation Measurement solutions for standardizing and automating processes. From fermentation profile design to scale-up and for determining the endpoint of fermentation instantly and reliably with no deviations on full-scale production. Vaccines production Collect only the virus fraction with correct density for best yield in purification operations/downstream processes.? Protein concentration and filtration Control retentate concentration for good permeability even with the smallest of particles.? Penicillin production Measure concentration of raw penicillin, monitor fermentation process and maintain optimal conditions with high yield during production.? L-Lysine evaporation process Control your evaporation process with an industrial process refractometer.?
Pharmaceutical fermentation Measurement solutions for standardizing and automating processes. From fermentation profile design to scale-up and for determining the endpoint of fermentation instantly and reliably with no deviations on full-scale production.
Vaccines production Collect only the virus fraction with correct density for best yield in purification operations/downstream processes.?
Protein concentration and filtration Control retentate concentration for good permeability even with the smallest of particles.?
Penicillin production Measure concentration of raw penicillin, monitor fermentation process and maintain optimal conditions with high yield during production.?
L-Lysine evaporation process Control your evaporation process with an industrial process refractometer.?
Medical applications Wound dressing, medical implants manufacturing and medical protective wear.? Download our application notes for more information.? Alginate wound dressings and fabrics Monitor alginate dope solution and coagulation bath concentrations in wet-spinning for operations for best fiber quality.? Medical implants and device surface treatments Monitor and control acid (for example nitric acid HNO3) during medical parts passivation to meet product specifications. Dipping baths in rubber and medical gloves manufacturing Ensure protective clothing's critical final?quality and durability?by measuring Total Dissolved Solids (TDS) in liquid latex, nitrile, vinyl or synthetic polyisoprene dipping baths.?
Alginate wound dressings and fabrics Monitor alginate dope solution and coagulation bath concentrations in wet-spinning for operations for best fiber quality.?
Medical implants and device surface treatments Monitor and control acid (for example nitric acid HNO3) during medical parts passivation to meet product specifications.
Dipping baths in rubber and medical gloves manufacturing Ensure protective clothing's critical final?quality and durability?by measuring Total Dissolved Solids (TDS) in liquid latex, nitrile, vinyl or synthetic polyisoprene dipping baths.?
Related products Vaisala K?PATENTS? Pharma Refractometer PR-43-PC for in-line liquid concentration measurements in pharmaceutical drug manufacturing and biochemicals processes Vaisala K?PATENTS? Sanitary Compact Refractometer PR-23-AC for Brix and concentration measurement
Vaisala K?PATENTS? Pharma Refractometer PR-43-PC for in-line liquid concentration measurements in pharmaceutical drug manufacturing and biochemicals processes
Blogs, webinars and success stories Read our latest blogs and listen to the webinar on pharmaceutical drug manufacturing.? Q&A from our webinar: Fast and efficient viral vaccines purification by sucrose density gradient Liquid Measurements Industrial Measurements Life Science Read more The six most important things to consider when selecting an in-line liquid measurement device for pharmaceutical drug manufacturing Liquid Measurements Industrial Measurements Life Science Read more Vaisala contributes to health and well-being, helping develop medicines such as a vaccine for COVID-19 Liquid Measurements Sustainability Life Science Read more Pagination Next page ??
Q&A from our webinar: Fast and efficient viral vaccines purification by sucrose density gradient Liquid Measurements Industrial Measurements Life Science Read more
The six most important things to consider when selecting an in-line liquid measurement device for pharmaceutical drug manufacturing Liquid Measurements Industrial Measurements Life Science Read more
Vaisala contributes to health and well-being, helping develop medicines such as a vaccine for COVID-19 Liquid Measurements Sustainability Life Science Read more
Fast and efficient viral vaccines purification by sucrose density gradient In this 30-minute webinar (+ 15 minutes for Q&A), Vaisala's Liquid Measurements pharmaceutical experts will explain the benefits of the refractive index technology and how it helps downstream processes during purification of viral vaccines manufacturing. Watch the webinar
Refractive index in development and production of Active Pharmaceutical Ingredients (APIs) Learn from real customer cases how in-line process refractometers can be used as a PAT tool for? standardizing and scaling-up APIs production.? Watch the webinar
Humidity and Temperature Probe HMP1 for wall mounting Vaisala HUMICAP? Humidity and Temperature Probe HMP1 is designed for measuring ambient measurement in indoor?spaces. HMP1 can... Read more
Humidity and Temperature Probe HMP1 for wall mounting Vaisala HUMICAP? Humidity and Temperature Probe HMP1 is designed for measuring ambient measurement in indoor?spaces. HMP1 can... Read more
Can't find your application? Only some examples of our refractometer applications are listed here. There are still hundreds more! Our application experts will help you. Tell us a bit more by filling the form or contact us. Contact Form
